Cumulative dose: inside the absence of the indisputable hypothesis about the pathophysiological system maybe associated, we used the cumulative dose mainly because it merged the two the period of treatment plus the somewhat variable day-to-day dose. For each person and every item, we computed the cumulative dose used throughout the study time window and transformed it into quite a few prescribed everyday doses (PDDs) by dividing it by the standard day by day dose for this item from the source cohort.
The deleterious results of benzodiazepines on memory are very well documented.22 23 No univocal pathophysiological mechanism, however, can be moderately Superior to clarify an elevated threat of dementia. Not long ago, a scientific overview underlined that benzodiazepine use induces equally non-amnestic and amnestic mild cognitive impairment59; a more rapidly progression of Alzheimer’s disease becoming observed during the latter type.
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Finally, we cannot rule out substitute hypotheses. Such as, stress and snooze Conditions, two of the key indications for benzodiazepines, could possibly be associated with early β amyloid lesions in Mind,forty two fifty eight and persistent mid-daily life panic can be associated with a greater risk of dementia in older people.
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Benzodiazepine use was assessed with dispensation promises recorded while in the RAMQ database. We thought of all benzodiazepines A part of the RAMQ list of reimbursed medication in the course of the study period of time (table 1⇓).
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